Laboratoire de recherche sur le métabolisme des substrats énergétiques

Nos recherches visent à comprendre :

  • L’importance, sur le plan physiologique, de l’activité des DPP4 et du clivage du substrat dans le contexte du diabète et des maladies cardiovasculaires.
  • Les sites cellulaires des DPP4 qui sont importants dans la régulation du métabolisme du glucose et des lipides.
  • Comment l’intestin s’adapte à l’ingestion de nourriture.
     
Publications 

Voir la liste des publications actuelles sur PubMed.

Publications choisies :

  • Morrow NM, Locatelli CAA, Hanson AA, Imran S, and Mulvihill EE. (2022). Adaptation to Short-term Extreme Fat Consumption Alters Intestinal Lipid Handling in Male and Female mice. BBA - Molecular and Cell Biology of Lipids. 
  • dos Santos T, Galipeau M, Schukarucha Gomes A, Lee D, Maghera J, Perera I, Polischevska K, Shayeganpour K, van Allen K, Wang Y, Greenberg M, Larsen M, Mulchandani C, Patton M, Ramdass S, Vafaeian K, Weisz T, Estall JL, Mulvihill EE, Screaton RA. (2022) Islet Biology Advances during COVID-19: Progress and Perspectives. Canadian Journal of Diabetes
  • Morrow NM, Trzaskalski NA, Hanson, AA, Fadzeyeva E, Telford DE, Choker S, Sutherland BG, Edwards JY, Huff MW, Mulvihill EE. (2022). Nobiletin Prevents High-fat diet induced Dysregulation of Intestinal Lipid Metabolism and Attenuates Post-prandial Lipemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 42(2): 127-144.
  • Ussher JRU, Greenwell A, Nguyen MA, Mulvihill EE. (2022). Cardiovascular Actions of Incretin Based Therapies: Integrating Mechanisms with Cardiovascular Outcomes Trials. Diabetes. 71(2): 173-183.
  • Dann MM, Clark SQ, Trzaskalski NA, Earl CC, Schepers LE, Pulente SM, Lennord EN, Annamalai K, Gruber JM, Cox AD, Lorenzen-Schmidt I, Seymour R, Kim KH, Goergen CJ, Mulvihill EE. (2022) Quantification of Murine Myocardial Infarct Size using 2D and 4D Ultra-High Frequency Ultrasound. American Journal of Physiology - Heart and Circulatory Physiology. 322(3): H359-H372.
  • Varin EM*, Mulvihill EE*, Baggio LL, Koehler J, Cao X, Seeley R, Drucker DJ. Distinct neural sites of GLP-1R expression mediate physiological vs. pharmacological control of incretin action. Cell Reports. 2019; 27: 3371–3384. (*Authors contributed equally). 
  • Varin EM*, Mulvihill EE*, Beaudry JL, Pujadas G, Fuchs S, Tanti Fazio JF, Kaur K, Matthews D, Baggio LL, Campbell JE, Drucker DJ. Hepatocyte-derived dipeptidyl peptidase 4 controls obesity-associated inflammation but not glucose homeostasis. Cell Metabolism. 2019; 29: 320-334. (*Authors contributed equally). 
  • Ussher JR, Campbell JE, Mulvihill EE, Baggio LL, Bates HE, Gopal K, Lamont BJ, Ilkayeva O, Ali S, Kim M, Kabir MG, Seino Y, Newgard CB, Suzuki J, Drucker DJ. Inactivation of the Glucose-Dependent Insulinotropic Peptide Receptor Improves Outcomes Following Experimental Myocardial Infarction. Cell Metabolism. 2018; 2: 450-460.
  • Mulvihill EE*, Varin EM*, Gladanac B, Campbell JE, Ussher JR, Baggio LL, Ayala J, Burmeister M, Yusta B, Holland D, Bang AKW,, Casper R, Ayala JE, Drucker DJ. Cellular ablation of Dpp4 reveals mechanism of glucose control. Cell Metabolism. 2017; 25(1): 152-165. (*Authours contributed equally)
Offres d'emploi 
Le laboratoire de Mme Mulvihill embauche! Faites parvenir votre C.V. et une lettre de présentation à emulvihill@ottawaheart.ca.
 

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