Objectifs de recherche :
- Comprendre l’importance, sur le plan physiologique, de l’activité des DPP4 et du clivage du substrat dans le contexte du diabète et des maladies cardiovasculaires.
- Comprendre les sites cellulaires des DPP4 qui sont importants dans la régulation du métabolisme du glucose et des lipides.
- Comprendre comment l’intestin s’adapte à l’ingestion de nourriture.
Publications
Voir la liste des publications actuelles sur PubMed.
Publications choisies :
- Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition Elodie M. Varin, Erin E. Mulvihill, Jacqueline L. Beaudry, Gemma Pujadas, Shai Fuchs, Jean-François Tanti, Sofia Fazio, Kirandeep Kaur, Xiemin Cao, Laurie L. Baggio, Dianne Matthews, Jonathan E. Campbell, Daniel J. Drucker Cell Metabolism [Epub ahead of print]
- GLP-1 Receptor Expression Within the Human Heart. Baggio LL, Yusta B, Mulvihill EE, Cao X, Streutker CJ, Butany J, Cappola TP, Margulies KB, Drucker DJ. Endocrinology. 2018 Apr 1;159(4):1570-1584.
- Regulation of intestinal lipid and lipoprotein metabolism by the proglucagon-derived peptides glucagon like peptide 1 and glucagon like peptide 2. Mulvihill EE. Curr Opin Lipidol. 2018 Apr;29(2):95-103.
- Dipeptidyl peptidase inhibitor therapy in type 2 diabetes: Control of the incretin axis and regulation of postprandial glucose and lipid metabolism. Mulvihill EE. Peptides. 2018 Feb;100:158-164.
- Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction. Ussher JR, Campbell JE, Mulvihill EE, Baggio LL, Bates HE, McLean BA, Gopal K, Capozzi M, Yusta B, Cao X, Ali S, Kim M, Kabir MG, Seino Y, Suzuki J, Drucker DJ. Cell Metab. 2018 Feb 6;27(2):450-460.e6.
- The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice. Baggio LL, Ussher JR, McLean BA, Cao X, Kabir MG, Mulvihill EE, Mighiu AS, Zhang H, Ludwig A, Seeley RJ, Heximer SP, Drucker DJ. Mol Metab. 2017 Nov;6(11):1339-1349.
- Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. Mulvihill EE, Varin EM, Gladanac B, Campbell JE, Ussher JR, Baggio LL, Yusta B, Ayala J, Burmeister MA, Matthews D, Bang KWA, Ayala JE, Drucker DJ. Cell Metab. 2017 Jan 10;25(1):152-165.
- Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis. Mulvihill EE, Burke AC, Huff MW. Annu Rev Nutr. 2016 Jul 17;36:275-99.
- Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice. Mulvihill EE, Varin EM, Ussher JR, Campbell JE, Bang KW, Abdullah T, Baggio LL, Drucker DJ. Diabetes. 2016 Mar;65(3):742-54.
- TCF1 links GIPR signaling to the control of beta cell function and survival. Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ. Nat Med. 2016 Jan;22(1):84-90.
Offres d'emploi
Le laboratoire de Mme Mulvihill embauche! Faites parvenir votre C.V. et une lettre de présentation à emulvihill@ottawaheart.ca.